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    A system-level approach identifies HIF-2α as a,critical regulator of chondrosarcoma progression

    November 26, 2023 5:29 pm Published by Comments Off on A system-level approach identifies HIF-2α as a,critical regulator of chondrosarcoma progression

    Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality. Here, we aim to uncover the transcriptional program directing such tumor progression in chondrosarcomas. We conduct weighted correlation network analysis to extract a characteristic gene module underlying chondrosarcoma malignancy. Hypoxia-inducible factor-2α (HIF-2α, encoded by EPAS1) [...]


    Constitutive activation of EGFR is associated with tumor progression and plays a prominent role in malignant phenotype of chondrosarcoma

    October 30, 2023 4:00 pm Published by Comments Off on Constitutive activation of EGFR is associated with tumor progression and plays a prominent role in malignant phenotype of chondrosarcoma

    Constitutive activation of EGFR is associated with tumor progression and plays a prominent role in malignant phenotype of chondrosarcoma Jun Qin,1 Irfan Shaukat,1 Didier Mainard,1 Patrick Netter,1 Lydia Barré,1 and Mohamed Ouzzine1 Author information Article notes Copyright and License information PMC Disclaimer Go to: Abstract Chondrosarcoma is a highly agressive cancer with currently no effective [...]


    Call for Action: Join the Chondrosarcoma Patient Registry before the first full analysis set for November 30.

    October 29, 2023 5:24 pm Published by Comments Off on Call for Action: Join the Chondrosarcoma Patient Registry before the first full analysis set for November 30.

    Chondrosarcoma Patient Registry https://chondrosarcoma.iamrare.org On November 30 the Chondrosarcoma will conduct the first full statistical analysis of the Chondrosarcoma Patient Registry. The analysis will focus on detailed patient profiling. In addition, patient characteristics between diagnosed/determined chondrosarcoma sub types will be compared and statistically evaluated. The main study outcomes will aim to thoroughly describe the profile [...]


    Videos from Virtual Dialogue 5 are posted on the Web Site.

    October 27, 2023 4:49 pm Published by Comments Off on Videos from Virtual Dialogue 5 are posted on the Web Site.

    Videos from Virtual Dialogue 5 are posted on the Web Site. We invite you to go to the Chondrosarcoma Foundation web site to review the presentations and the open discussion from the Fifth International Virtual Dialogue recently held on October 4. They were posted today and ready to be viewed. Presentations from: William Tap, M.D. [...]


    New Publication: Chondrosarcoma: What You Need to Know

    October 26, 2023 1:16 am Published by Comments Off on New Publication: Chondrosarcoma: What You Need to Know

    New Publication: Chondrosarcoma: What You Need to Know A third publication created by the Chondrosarcoma Foundation’s Patient, Family, Caregiver Advisory Board and the Marketing / Graphics team at Inhibrx provides straightforward information on chondrosarcoma for newly diagnosed patients as well as those who have a recurrence. All three publications can be found on our web [...]


    CS Foundation Fund Raiser: Steppin’ for a Cause

    October 8, 2023 7:10 pm Published by Comments Off on CS Foundation Fund Raiser: Steppin’ for a Cause

    Steppin’ For A Cause: 5K Walk / Run October 21, 2023 10:00AM EST Allen’s Pond, Bowie, Maryland Please join us for our annual fund raising event to honor Shayna Kramer by carrying out her wish to help others that have the same rare bone cancer: Chondrosarcoma that she dis. You can register using the QR [...]


    Last Call to Register for the Chondrosarcoma Foundation’s Virtual Dialogue

    October 1, 2023 4:13 pm Published by Comments Off on Last Call to Register for the Chondrosarcoma Foundation’s Virtual Dialogue

    Future Initiatives in the Diagnosis and Treatment of Chondrosarcoma Chondrosarcoma Foundation: Fifth International Virtual Dialogue (VIA Zoom) Date: Wednesday, October 4, 2023 Time: 7:00PM – 9:00PM (EST / New York) Last chance to register. The event is this coming Wednesday night. It is very important that you are aware of your treatment options as well [...]


    Clinico-genomic profiling of conventional and dedifferentiated chondrosarcomas reveals ,TP53 mutation to be associated with worse outcomes

    September 30, 2023 1:33 am Published by Comments Off on Clinico-genomic profiling of conventional and dedifferentiated chondrosarcomas reveals ,TP53 mutation to be associated with worse outcomes

    Paper recently published in Clinical Cancer Research on genetic sequencing of conventional and dedifferentiated chondrosarcoma from two of our board members at MD Anderson in Houston, Texas: Anthony Conley, M.D. and Shaan Mohahmad Razza, M.D. For more information: https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-23-1703/729257/Clinico-genomic-profiling-of-conventional-and ABSTRACT Purpose: Chondrosarcomas are the most common primary bone tumor in adults. IDH1 and IDH2 mutations [...]


    Chondrosarcoma Foundation Virtual Dialogue: October 4, 2023: 7:00PM – 9:00PM EST / New York time via Zoom

    September 18, 2023 4:09 pm Published by Comments Off on Chondrosarcoma Foundation Virtual Dialogue: October 4, 2023: 7:00PM – 9:00PM EST / New York time via Zoom

    Two weeks from this Wednesday. We want to encourage you to attend our upcoming Virtual Dialogue. We bring together the diverse group of clinical / research/ medical / sarcoma experts with chondrosarcoma patients, families and caregivers. The focus is on future initiatives in diagnosing and treating chondrosarcoma but it will also take inventory of present [...]


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